DeLisle started in a few animation series and, since then, has been featured in numerous video games.
She is best-known for her sinister voice of the evil sister "Vicky" in the Nickelodeon TV series, "Fairly OddParents" (2001-2013), also she leading voiced of "Todd McNulty" in the Nickelodeon's Rugrats (1997-2003), as well as the equally evil "Mandy" in the Cartoon Network TV show, "The Grim Adventures of Billy and Mandy" (2001 - 2007). She voiced evil, cold "Mandy" again in two more films about Billy and Mandy, "Billy and Mandy Big Boogie Adventure" (2007) and "The Grim Adventures of KND" (2007), opposite'Richard Steven Horvitz' (Billy) and Greg Eagles (Grim).
In 2002, Grey DeLisle married musician Murry Hammond, the bassist for the band, Old 97's. Their first child, Jefferson Texas Hammond, was born in 2007, in Los Angeles, California.