Since its pilot episode, Rugrats has had many changes in its production of episodes and characters.
- The original Rugrats logo was different compared to the usual.
- Tommy is voiced by Tami Holbrook.
- The design of Tommy is very different compared to the next episodes.
- The pilot was made in 1990 but never aired on Nickelodeon. However, it can be found on YouTube, and on the Decades in Diapers Collection.
- Rugrats begins running episodes on Nickelodeon during the 10:30AM Sunday time slot.
- Tommy wears a red-orange shirt rather than his blue shirt in a few episodes.
- A woman with glasses who by many is assumed to be Chuckie's mother makes a cameo in the episode Barbecue Story (This is not confirmed by Klasky Csupo).
- The episode Waiter, There's a Baby in My Soup is the only episode not to have a title card, but it was added later, first on a rerun in the Summer of 1997.
- This season has a different look compared to the other seasons. The animation, which was done in Taiwan by Wang Film Productions is quite crude, yet smooth, and character designs are slightly different.
- Production is switched to many Korean companies, mainly Anivision.
- The 22nd episode of season 3 Pickles Vs. Pickles is very different compared to the next season episodes. It is the last episode containing a little dark tone (due the fact of the main plot it's about Drew's nightmare).
- In the middle of Season 3, the animation started to get cruder.
- After "A Rugrats Passover" aired on March 18, 1995, the show was cancelled.
- Rugrats was uncancelled, and given a heavier marketing campaign, and featured more detailed art.
- Beginning here, the babies would start to talk more and Tommy would no longer have his own adventures.
- Phil has ear lobes.
- Mark Mothersbaugh's music toned down, compared to his more serious soundtrack of the previous seasons. (For example, the music is more serious in Chuckie's Wonderful Life - an episode of the "original" seasons ).
- Bob Mothersbaugh replaces Denis M. Hannigan as the secondary musician of the new seasons.
- At the end of the show they started to use the Klasky Csupo robot logo
- An all new opening was created including Susie, Dil, and Kimi.
- Kimi, Fifi, and Kira are added in Rugrats in Paris.
- Chuckie was voiced by Nancy Cartwright.
- The Wild Thornberrys make a crossover with The Rugrats in Rugrats Go Wild .
- The Rugrats end with it continuing as All Grown Up !
- Phil no longer has ear lobes.
- Spike doesn't appear very often.